The sanctification of Holy Chrism took place with special splendor and solemnity in the morning of Holy Thursday, 21 April, 2022, at the Ecumenical Patriarchate during the Patriarchal and Synodal Divine Liturgy, presided by His All-Holiness Ecumenical Patriarch Bartholomew in concelebration with the members of the Holy and Sacred Synod.

Holy Chrism is consecrated on Holy Thursday about every ten years at the Ecumenical Patriarchate for use in the sacrament of Holy Chrismation, for the reception of Christian converts joining the Orthodox Church and for the consecration of holy churches and altars. For more than a millennium, this sacred ceremony is taking place at the Ecumenical Patriarchate, the first throne of world Orthodoxy, with the presence of representatives from different local Orthodox Churches, thus manifesting the bond of unity all Orthodox Christians throughout the world.